Process for preparing 5-(2-chlorobenzyl)-4,5,6,7-tetrahydrothieno (3,2-C)pyridine
AssigneesNisshin Flour Milling Co., Ltd., Nisshin Chemicals Co., Ltd.
InventorToshio Suguro
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Abstract
An improved process for the preparation of 5-(2-chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine and acid addition salts thereof, which are useful as a medicine. This process comprises effecting reaction between 4,5,6,7-tetrahydrothieno[3,2-c]pyridine and 2-chlorobenzyl halide in the presence of a phase transfer catalyst.
Claims8
A process for preparing 5-(2chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine of the formula (I) ##STR8## and acid addition salts thereof, which comprises reacting a compound of the formula (II) ##STR9## with a compound of the formula (III) ##STR10## wherein X represents Cl, Br or I, in the presence of a phase transfer catalyst and a base.
Dependencies are inferred from the claim text.