Biosoluble ocular insert
AssigneeMerck & Co., Inc.
InventorsJoseph V. Bondi, Richard J. Harwood
Life of this patent
Estimating the term…
Abstract
Ocular inserts with or without pharmacologically active agents comprising low molecular weight polymers have a lower propensity to cause blurred vision compared with inserts prepared from high molecular weight hydroxypropyl cellulose. When an enteric coating material is included as a constituent of the matrix there is provided a means for controlling and predicting dissolution rates of the insert to yield a prolonged residence time.
Claims2
A non-vision blurring ocular insert comprising 75-100% of a matrix comprising, in percentage parts by weight:
- (i) 15% polyvinyl alcohol (m.w. 2000-3000);
- (ii) 10% glycerin;
- and
- (iii) 75% hydroxypropylmethylcellulose phthalate, and 0-25% of a pharmacologically active agent.
A non-vision bluring ocular insert comprising 75-100% of a matrix comprising, in percentage parts by weight:
- (i) 70% polyvinyl alcohol (m.w. 2000-3000);
- (ii) 5% glycerin;
- and
- (iii) 25% mannitol;
- and 0-25% of a pharmacologically active agent.
Dependencies are inferred from the claim text.