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US 4,729,990 AGranted
Substituted penem derivatives
AssigneeFarmitalia Carlo Erba S.p.A.
InventorsMarco Alpegiani, Angelo Bedeschi, Maurizio Foglio, Giovanni Francheschi, Ettore Perrone
Life of this patent
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Abstract
Antibacterial compounds of formula (I) ##STR1## wherein, R.sub.1 ' is alkyl or hydroxyalkyl; R.sub.2 is hydrogen or a carboxy protecting group; and Y' is a group-S-heterocyclic or pyridyl, which group may be substituted, and pharmaceutically or veterinarily acceptable salts thereof and pharmaceutical compositions containing the same.
Claims9
A compound of the following formula (Ia):
- ##STR96## wherein R'.sub.1 is a C.sub.1 -C.sub.6 alkyl group substituted by hydroxy;
- R.sub.2 is hydrogen;
- Y' is a group --S-Het' wherein Het' represents:
- (a) 5-oxo-6-hydroxy-2,5-dihydro-1,2,4-triazinyl or 5-oxo-6-hydroxy-4,5-dihydro-1,2,4-triazinyl, both optionally substituted by a C.sub.1 -C.sub.3 alkyl group;
- or
- (b) tetrazolo-pyridazinyl optionally substituted by a group ##STR97## wherein each of R' and R" is independently hydrogen or C.sub.1 -C.sub.3 alkyl group;
- and the pharmaceutically acceptable salts thereof.
4 more elements
A compound selected from the group consisting of
- (5R,6S)-6-[1(R)-hydroxyethyl]-2-(tetrazolo[1,5-b]pyridazin-6-yl)-thiomethyl -penem-3-carboxylic acid;
- (5R,6S)-6-[1(R)-hydroxyethyl]-2-(8-aminotetrazolo[1,5-b]pyridazin-6-yl)-thi omethyl-penem-3-carboxylic acid;
- (5R,6S)-6-[1(R)-hydroxyethyl]-2-(2-methyl-5-oxo-6-hydroxy-2,5-dihydro-1,2,4 -triazin-3-yl)-thiomethyl-penem-3-carboxylic acid;
- (5R,6S)-6[1(R)-hydroxyethyl]-2-(4-methyl-5-oxo-6-hydroxy-4,5-dihydro-1,2,4- triazin-3-yl)-thiomethyl-penem-3-carboxylic acid;
- and the pharmaceutically acceptable salts thereof.
2 more elements
Dependencies are inferred from the claim text.