Back to results
US 4,729,985 AGranted
Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues
AssigneePfizer Inc.
InventorsEdward F. Kleinman, Robert L. Rosati, Jasjit S. Bindra
Life of this patent
Estimating the term…
Abstract
A series of novel polypeptide derivatives, containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues, which are useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin. Particularly valuable precursors for many of these compounds are certain other 5-amino-2,5-disubstituted-4-hydroxypentanoic acid derivatives.
Claims15
A polypeptide derivative of the formula ##STR22## or a pharmaceutically acceptable salt thereof, wherein ##STR23## R is hydrogen or an amino protecting acyl group having a molecular weight of less than 500;
- R.sup.1 and R.sup.2 are each independently hydrogen, (C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkenyl, phenyl, naphthyl, (C.sub.4 -C.sub.7)cycloalkyl, (C.sub.4 -C.sub.7)cycloalkenyl, (C.sub.7 -C.sub.9)phenylalkyl, (C.sub.11 -C.sub.13) naphthylalkyl or (C.sub.5 -C.sub.10) (cycloalkyl)alkyl;
- and
- Y is OR.sup.9 or NR.sup.9 R.sup.10 ;
- where R.sup.9 and R.sup.10 are each independently hydrogen, (C.sub.1 -C.sub.5)alkyl, (C.sub.4 -C.sub.7)cycloalkyl or benzyl.
1 more element
Dependencies are inferred from the claim text.