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AssigneeCompagnie Oris Industrie S.A.
InventorsJeanne Berthet, Marie-Francoise Blin, Gilbert Gaussens
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Inert cross-linked copolymer able to absorb and then progressively release a pharmaceutically active substance, wherein it is constituted by a powder of a cross-linked copolymer comprising 30 to 80% by weight of monounsaturated alkyl acrylate and/or methacrylate; 5 to 68% by weight of acrylic and/or methacrylic acid; and 2 to 15% by weight of bifunctional or trifunctional acrylate and/or methacrylate. A mixture of monounsaturated alkyl acrylate and/or methacrylate, acrylic and/or methacrylic acid, and bifunctional or trifunctional acrylate and/or methacrylate monomers is polymerized in accordance with a free radical polymerization mechanism. The support is used for the preparation of a delayed action or release medicament.
A process for slow release of a pharmaceutically active substance soluble in aqueous or alcoholic solutions which comprises:
A pharmaceutical composition comprising a powder of a crosslinked copolymer support comprising 30-80% by weight of a monounsaturated alkyl acrylate and/or alkyl methacrylate wherein the alkyl acrylate is selected from the group consisting of butyl, hexyl and heptylacrylates and the methacrylate is selected from the group consisting of methyl, ethyl, butyl, hexyl and heptylmethacrylates, 5-68% by weight of acrylic and/or methacrylic acid, and 12-15% by weight of bifunctional or trifunctional acrylate and/or methacrylate, selected from the group consisting of polyethylene glycol diacrylate, trimethylol propane triacrylate and trimethylol propane trimethacrylate, and a pharmaceutically active substance soluble in an aqueous or alcoholic solution absorbed thereinto.
A process for slow release of a pharmaceutically active substance soluble in aqueous or alcoholic solutions which comprises:
Dependencies are inferred from the claim text.