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US 4,729,380 AGranted
Iridium 191-M generator
AssigneeChildren's Medical Center Corporation
InventorsSalvador Treves, Chris C. Cheng
Life of this patent
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Abstract
Potassium osmate, of the formula K.sub.2 Os O.sub.2 (OH).sub.4), used to make a column for the generation of Ir-191 m, which is used in first pass angiography to detect cardiac defects in patients.
Claims3
An apparatus for generating Iridium-191 comprising
- a generator column containing a resin loaded with a solution comprising a mixture of K.sub.2 (OsO.sub.2 (OH).sub.2 Cl.sub.2) and K.sub.2 (OsO.sub.2 Cl.sub.4),
- an eluant injector, positioned upstream from said generator column,
- a scavenger column connected to and positioned downstream from said generator column,
- an eluate injector, including a needle for insertion into a blood vessel of a human patient, positioned downstream from said scavenger column, and
- a lead container enclosing said generator and scavenger columns.
2 more elements
Apparatus for generating iridium-191 m to be administered to a human, said apparatus comprising an eluate injector comprising:
- (a) a generator column containing a resin loaded with the solution comprising a mixture of K.sub.2 (OsO.sub.2 (OH).sub.2 Cl.sub.2) and K.sub.2 (OsO.sub.2 Cl.sub.4), and
- (b) means for administering iridium-191 m eluate generated from said column to said human.
A method of generating iridium-191 m comprising:
- (a) providing an apparatus comprising an eluate injector, said injector comprising:
- (1) a generator column containing a resin, and
- (2) means for administering iridium-191 m eluate generated from said column to a human;
- (b) providing potassium osmate;
- (c) dissolving said potassium osmate in HCl to form a solution comprising a mixture of K.sub.2 (OsO.sub.2 (OH).sub.2 Cl.sub.2) and K.sub.2 (OsO.sub.2 Cl.sub.4);
- (d) loading said solution onto said generator column;
- and
- (e) eluting iridium-191 m from said generator column using an eluant capable of eluting iridium-191 m.
5 more elements
Dependencies are inferred from the claim text.