Selective incorporation of a polymer into implantable biological tissue to inhibit calcification
AssigneeBaxter Travenol
InventorAws S. Nashef
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Abstract
A process for selectively incorporating biocompatible polymers in the interstices of implantable biological tissue while leaving the outer surface of the tissue substantially free of bonded polymer. The process involves covalently binding a monomer to the tissue, contacting the tissue with a free-radical initiator, then contacting the tissue with a solution containing a second monomer and a free-radical scavenger, thereby promoting selective polymerization of the second monomer with the portion of covalently-bound first monomer which is located in the interstices of the tissue.
Claims29
A process for treating animal biological tissue prior to implantation in an animal to reduce calcification of said tissue after implantation comprising the steps of:
- (a) fixing said tissue under tissue-fixing conditions;
- (b) contacting said fixed tissue with a first solution of one or more monomers under conditions sufficient to covalently bond said monomer(s) to the tissue;
- (c) contacting said tissue with a polymerization initiator;
- and
- (d) contacting said tissue with a second solution containing one or more monomers or oligomers under polymerization conditions in presence of a polymerization-inhibiting free-radical scavenger, such that the second monomer(s) or oligomer(s) polymerize with said covalentyl-bound first monomer(s) and the resulting polymer is concentrated in the interstices of the tissue.
A process for treating animal biological tissue prior to implantation in an animal to reduce calcification of said tissue after implantation comprising steps of
- (a) fixing said tissue under tissue-fixing conditions;
- (b) contacting said tissue with a first solution containing one or more monomers capable of further polymerization under conditions sufficient to impregnate said monomer(s) in said tissue;
- and
- (c) contacting said tissue with a second solution containing one or more monomers or oligomers under polymerization conditions in the presence of a polymerization-inhibiting free-radical scavenger, such that the second monomer(s) or oligomer(s) polymerize with said first monomer(s) and the resulting polymer is concentrated in the interstices of the tissue.
Dependencies are inferred from the claim text.