Uniquely non-mutagenic substituted nitroimidazole
AssigneeMerck & Co., Inc.
InventorsEdward S. Bagan, Gerald T. Miwa
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Abstract
There is disclosed a substituted nitroimidazole compound, 1-methyl-2-methylsulfonyl-4-nitroimidazole which is an antiprotozoal and bactericidal compound with the unique and surprising property of being totally non-mutagenic and thus of a much higher degree of safety than is found with other nitroimidazoles. Compositions and methods for the antiprotozoal and bactericidal uses of such compounds are also disclosed.
Claims2
A method for the non-mutagenic treatment of the protozoal and bacterial diseases trichomoniasis, amoebiasis, trypanosomiasis, enterohepatitis, and schistosome and pleuro-pneumonia like organism infections in animals requiring treatment for such diseases which comprises orally or topically administering from 25 to 1000 mg per day of 1-methyl-2-methylsulfonyl-4-nitroimidazole.
Dependencies are inferred from the claim text.