Method of treating psoriasis
AssigneeThe General Hospital Corporation
InventorsMichael F. Holick, Julia McLaughlin
Life of this patent
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Abstract
A method of treating psoriasis in a patient which comprises administering to said patient an effective amount of a vitamin D compound which is capable of stimulating the differentiation of cultured tumor cells or normal rodent or human fibroblasts or keratinocytes in vitro.
Claims15
A method of treating the disease of psoriasis in a patient affected by said disease which comprises administering to said patient by oral or parenteral means an effective amount of a vitamin D compound, which compound when tested in vitro is capable of stimulating the differentiation of cultured tumor cells.
A method of treating the disease of psoriasis in a patient affected by said disease which comprises administering to said patient by oral or parenteral means an effective amount of a vitamin D compound, which compound when tested in vitro is capable of stimulating the differentiation of cultured normal rodent or human keratinocytes or fibroblasts.
A method of treating the disease of psoriasis in a patient affected by said disease which comprises administering to said patient by oral or parenteral means an effective amount of a vitamin D compound, which compound when tested in vitro is capable of inhibiting normal fibroblast cell growth.
A method of treating the disease of psoriasis in a patient affected by said disease which comprises administering to said patient by oral or parenteral means an effective amount of a vitamin D compound, which compound when tested in vitro is capable of increasing the enzymatic activity of transglutaminase in cultured keratinocytes.
A method of treating the disease of psoriasis in a patient affected by said disease which comprises administering to said patient by oral or parenteral means an effective amount of a vitamin D compound, which compound when tested in vitro is capable of stimulating the differentiation of a cultured cell said cell selected from the group consisting of (a) a cultured tumor cell and (b) a cultured normal rodent or human, keratinocyte or fibroblast cell;
- said vitamin D compound having the formula (I):
- ##STR5## wherein the bond between carbons C-22 and C-23 is a single or double bond;
- Y.sup.1 is hydrogen, F, CH.sub.3 or CH.sub.2 CH.sub.3 ;
- Z.sup.1 is F, H or X.sup.1
- Q.sup.a is CF.sub.3 or CH.sub.2 X.sup.1 ;
- Q.sup.b is CF.sub.3 or CH.sub.3 ;
- R is a double bond or an epoxy group;
- wherein X.sup.1 is selected from the group consisting of hydrogen and OH.
A method of treating the disease of psoriasis in a patient affected by said disease which comprises administering to said patient by oral or parenteral means an effective amount of a vitamin D compound, which compound when tested in vitro is capable of stimulating the differentiation of a cultured cell, said cell selected from the group consisting of (a) a cultured tumor cell and (b) a cultured normal rodent or human keratinocyte or fibroblast cell;
- said vitamin D compound having the formula (II):
- ##STR6## wherein the bond between carbons C-22 and C-23 is a single or double bond;
- Y.sup.2 is hydrogen, fluorine, methyl, or ethyl;
- Z.sup.2 is F, H or X.sup.2
- Q.sup.a is CF.sub.3 or CH.sub.2 X.sup.2 ;
- Q.sup.b is CF.sub.3 or CH.sub.3 ;
- R is a double bond or an epoxy group;
- X.sup.2 is selected from the group consisting of hydrogen, and OR.sup.1,
- wherein R.sup.1 is hydrogen or a straight or branched chain glycosidic residue containing 1-20 glycosidic units per residue, or R.sup.1 is an orthoester glycoside moiety of the formula (III):
- ##STR7## where A represents a glycofuranosyl or glucopyraosyl ring;
- R.sup.2 is hydrogen, lower alkyl, aralkyl, or aryl;
- and
- R.sup.3 is hydrogen or a straight or branched chain glycosidic residue containing 1-20 glycosidic units per residue, with the proviso that at least one of the R.sup.1 is either a glycosidic residue or an orthoester glycoside moiety.
Dependencies are inferred from the claim text.