Type-specific opsonic antibodies evoked with a synthetic peptide of streptococcal M protein conjugated to polylysine without adjuvant
AssigneeThe University of Tennessee Research Corporation
InventorEdwin H. Beachey
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Abstract
A polypeptide having the formula Asn-Phe-Ser-Thr-Ala-Asp-Ser-Ala-Lys-Ile-Lys-Thr-Leu-Glu-Ala-Glu-Lys-Ala-Al a-Leu-Ala-Ala-Arg-Lys-Ala-Asp-Leu-Glu-Lys-Ala-Leu-Glu-Gly-Ala-Met is conjugated to polylysine.
Claims2
An immunogenic biological composition which comprises a biologically acceptable diluent and in an amount sufficient to elicit opsonic antibodies to Streptococcus pyogenes and not be serologically cross-reactive with tissue antigens of the heart, a polypeptide conjugae having the amino acid sequence Asn-Phe-Ser-Thr-Ala-Asp-Ser-Ala-Lys-Ile-Lys-Thr-Leu-Glu-Ala-Glu-Lys-Ala-Al a-Leu-Ala-Ala-Arg-Lys-Ala-Asp-Leu-Glu-Lys-Ala-Leu-Glu-Gly-Ala-Met conjugated to polylysine.
Dependencies are inferred from the claim text.