Boxazomycin A and B, new antibiotics containing benzoxazole nucleus
AssigneeBristol-Myers Company
InventorsKyoichiro Saitoh, Masataka Konishi, Koji Tomita
Life of this patent
Estimating the term…
Abstract
The novel antibiotics boxazomycin A and B, which have the formula: ##STR1## wherein R is --CH.sub.2 OH for boxazomycin A; and R is --CH.sub.3 for boxazomycin B. These new antibiotics, which are produced by cultivating a novel strain of Pseudonocardia (ATCC 53205), inhibit growth of aerobic Gram-positive bacteria and anaerobes with enhanced activity observed in acidic medium.
Claims3
The method for producing boxazomycin A which comprises cultivating Pseudonocardia strain No. G495-11 (ATCC 53205) or a boxazomycin A-producing mutant thereof under aerobic conditions in an aqueous medium containing assimilable sources of carbon and nitrogen until a substantial amount of boxazomycin A is produced and thereafter recovering boxazomycin A from the culture medium.
The method for producing boxazomycin B which comprises cultivating Pseudonocardia strain No. G495-11 (ATCC 53205) or a boxazomycin B-producing mutant thereof under aerobic conditions in an aqeuous medium containing assimilable sources of carbon and nitrogen until a substantial amount of boxazomycin B is produced and thereafter recovering boxazomycin B from the culture medium.
A biologically pure culture of the microorganism Pseudonocardia strain No. G495-11 (ATCC 53205), said culture being capable of producing the antibiotics boxazomycin A and B in a recoverable quantity upon aerobic cultivation in an aqueous nutrient medium containing assimilable sources of carbon and nitrogen.
Dependencies are inferred from the claim text.