Apparatus for the chemical synthesis of oligonucleotides

Apparatus for simultaneously carrying ot a multiplicity of different chemical and biochemical syntheses on solid supports comprising a multiplicity of support plates each formed with passageways therethrough, one of said passageways through each plate containing a reaction chamber having a solid support;

• said other passageways each providing a by-pass channel without a solid support, said by-pass channels and reaction chamber being disposed equi-angularly and at the same radial distance about an axis of each plate, means for holding said plates in rotatable alignment about said axis in compression and in face-to-face fluid tight relationship, holding means including end plates complementary to the plates and each formed with a blank position and passages for at least one reactant stream, and means for independently rotating each plate whereby each rotation chamber of each plate may be isolated from or positioned in a selected reactant stream.