Diafiltration method
AssigneeMillipore Corporation
InventorsAnthony J. DiLeo, Gaston de los Reyes, Lisa M. Waranch
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Abstract
A process and apparatus is provided for separating whole blood from a patient into a cellular component and a plasma component and for separating the plasma component into a high molecular weight plasma fraction and a low molecular weight plasma fraction and wherein anticoagulant is added to the whole blood and a physiologically acceptable liquid diluent is added to the plasma component. The rate of addition of the diluent is governed by the following equation: ##EQU1## called Equation 1.
Claims4
The process for separating whole blood into a cellular component and a plasma component and for separating said plasma component into a high molecular weight plasma fraction and a low molecular weight plasma fraction consisting essentially of:
- (a) withdrawing whole blood from a patient,
- (b) continuously introducing anticoagulant into whole blood,
- (c) passing the mixture of whole blood and anticoagulant through a first separating means adapted to separating whole blood to form a cellular component and a plasma component,
- (d) adding a physiologically acceptable liquid diluent to said plasma component at a diluent flow rate defined by Equation 1:
- ##EQU6## thereby to form a mixture of said diluent and said plasma component, (e) separating said mixture of diluent and said plasma component into a high molecular weight plasma fraction and a low molecular weight plasma fraction,
- (f) recycling at least a portion of said high molecular weight fraction to be admixed with said mixture of diluent and said plasma component, and
- (g) recycling said cellular component and said low molecular weight plasma component directly to said patient.
Dependencies are inferred from the claim text.