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US 4,727,156 AGranted
3-(Substituted phenyl)-3-(1H-imidazol-1-ylmethyl)-2-methyl-5-{[(substituted phenyl)thio]me}isoxazolidine derivatives
AssigneePennwalt Corporation
InventorsVassil St. Georgiev, George B. Mullen
Life of this patent
Estimating the term…
Abstract
3-(Substituting phenyl)-3-(1H-imidazol-1-ylmethyl)-2-methyl-5-{[(substituted phenyl)thio]m ethyl}isoxazolidines in which hydrogens of their phenyl rings may be replaced by halogen, lower alkoxy, lower alkyl or nitro groups, and the sulfur atom may be oxidized, are useful as antifungal agents.
Claims16
A compound of the formula:
- ##STR4## or a pharmaceutically acceptable acid addition salt thereof, in the form of their enantiomers, or mixtures of their enantiomers including diastereoisomeric pairs of such enantiomers, wherein;
- a=1 or 2,
- b=1 or 2,
- R.sup.1 is selected from hydrogen, halogen, lower alkyl, lower alkoxy, and combinations thereof, provided that the ortho position is hydrogen,
- R.sup.2 is selected from hydrogen, halogen, lower alkyl, lower alkoxy, nitro, and combinations thereof, and
- n=0 to 2.
3 more elements
Dependencies are inferred from the claim text.