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US 4,727,147 AGranted
Optically active 1-(4-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinolinium acetates
AssigneeMerck Patent GmbH
InventorsWilli Wintermeyer, Fritz Reiff, Hans R. Muller, Josef Conti
Life of this patent
Estimating the term…
Abstract
Racemic 1-(4-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline can be resolved by seeding the supersaturated solution of racemic 1-(4-methoxybenzyl)-octahydroisoquinolinium acetate with its enantiomeric forms and crystallizing the optically active acetate corresponding to the configuration of the seed crystals. The continuous form of the process permits obtaining the two enantiomers together.
Claims4
(R,S)-1-(4-Methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinolinium acetate, or the R-acetate or the S-acetate.
Dependencies are inferred from the claim text.