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US 4,727,076 AGranted
Tetrahydroquinolinylalkyl amino pyridones and ring homologues thereof, useful as histamine-H.sub.1 -receptor antagonists
AssigneeSmith Kline & French Laboratories Limited
InventorsDavid G. Cooper, George S. Sach
Life of this patent
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Abstract
The invention provides tetrahydroquinolinylalkylamino pyrimidones, and ring homologues thereof, of the general formula (1): ##STR1## wherein R.sup.1 is hydrogen or an alkyl, alkoxy, halogen or amino-substituent, m and n are each 2, 3 or 4 and R.sup.2 is hydrogen, alkyl or variously substituted benzyl. The compounds are useful as histamine-H.sub.1 -receptor antagonists.
Claims9
A compound of formula (1):
- ##STR11## or a pharmaceutically acceptable acid addition salt thereof in which R.sup.1 is hydrogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halogen or amino;
- n is 2, 3 or 4;
- m is 2, 3 or 4;
- and
- R.sup.2 is hydrogen or CH.sub.2 R.sup.3 where
- R.sup.3 is hydrogen, C.sub.1-6 alkyl, or C.sub.3-8 cycloalkyl;
- phenyl optionally substituted by one or more C.sub.1-6 alkyl, C.sub.1-6 alkoxy, nitro or hydroxy groups or halogen atoms, or a methylenedioxy group;
- pyridyl or pyridyl-N-oxide optionally substituted by one or more C.sub.1-6 alkyl, C.sub.1-6 alkoxy, hydroxymethyl or hydroxy groups or halogen atoms;
- or a pyridone group in which the nitrogen atom is substituted by C.sub.1-6 alkyl.
6 more elements
Dependencies are inferred from the claim text.