2-(phenylmethylene)-1-(diaminoalkoxy) cycloalkanes and their pharmaceutical uses

A method of combating angina in a patient suffering therefrom which comprises:

• treating said patient with a pharmaceutical composition containing an effective amount of a compound of the formula (I) ##STR8## wherein n is 4-6 and when n is 4,
• R stands for phenyl, A is trimethyllene and R.sup.1 and R.sup.2 each stand for isopropyl or together with the adjacent nitrogen atom form a N-phenyl-piperazine group;
• or
• R stands for phenyl, A is ethylene and R.sup.1 and R.sup.2 each stand for isopropyl;
• or
• R stands for phenyl, A is --CH.sub.2 --CH(CH.sub.3)-- and R.sup.1 and R.sup.2 each stand for methyl;
• or
• R stands for 4-chloro-phenyl, A is trimethylene and R.sup.1 and R.sup.2 each represent isopropyl;
• or
• R stand for 4-chloro-phenyl, A is ethylene and R.sup.1 and R.sup.2 each stand for methyl;
• or
• when n is 5,
• R stands for phenyl, A is ethylene and R.sup.1 and R.sup.2 are identical and each stand for methyl or isopropyl;
• or
• R stands for phenyl, A is --CH.sub.2 --CH(CH.sub.3)-- and R.sup.1 and R.sup.2 are methyl;
• or
• R stands for 3-chloro-phenyl, A is trimethylene and R.sup.1 and R.sup.2 together with the adjacent nitrogen atom form a N-benzylpiperazine group;
• or
• when n is 6,
• R stands for phenyl, A is trimethylene and R.sup.1 and R.sup.2 each stand for methyl;
• or
• R stands for phenyl, A is ethylene and R.sup.1 and R.sup.2 each stand for isopropyl;
• with the proviso that when n is 5 and R is phenyl and A is ethylene and R.sup.1 and R.sup.2 each are isopropyl, the compound of the general formula (I) is of Z,E configuration and in all the other cases the compound of the formula (I) is of E,E-configuration, and pharmaceutically acceptable acid addition salts thereof.