Pyrimidine derivatives and composition of the same

Pyrimidine derivatives of the formula:

• ##STR14## wherein Ar is phenyl group substituted with 1 to 3 substituent(s) selected from the group consisting of nitro, halo(lower)alkyl, lower alkoxy and a group of the formula:
• ##STR15## (in which l, R.sup.4, R.sup.5 and R.sup.6 are each as defined in the below);
• R.sup.1 is lower alkoxycarbonyl group, lower alkanoyl group, hydroxy(lower)alkyl group or a group selected from the following formulas:
• ##STR16## (in which R.sup.7, R.sup.8, and A are each as defined in the below);
• R.sup.2 is hydrogen, lower alkyl group or a group of the formula:
• ##STR17## (in which Q, R.sup.7 and R.sup.8 are each as defined in the below);
• R.sup.3 is lower alkyl or phenyl group;
• l is an integer of 0, 1 to 6;
• R.sup.4, R.sup.5 and R.sup.6 are each hydrogen or halogen;
• R.sup.7 and R.sup.8 are each hydrogen, optionally substituted N-containing heterocyclic group selected from the group consisting of imidazolinyl and piperidyl or lower alkyl group optionally substituted with 1 to 3 substituent(s) selected from the group consisting of mono- or di(lower)alkylamino, and optionally substituted N-containing heterocyclic group selected from the group consisting of morpholinyl and pyrrolidinyl;
• or
• R.sup.7 and R.sup.8 are taken together to form an optionally substututed N-containing heterocyclic group with the adjacent nitrogen atom selected from the group consisting of 1-piperazinyl, 1-homopiperazinyl, morpholino, thiomorpholino, piperidino, 1,4-diazabicyclo [4.3.0]nonan-4-yl, 1-imidazolyl and phthalimido;
• A and Q are each straight or branched lower alkylene group which may be substituted with a lower alkylidene;
• provided that R.sup.1 is a group of the formula:
• ##STR18## (in which R.sup.7, R.sup.8 and A are each as defined above) when R.sup.2 is hydrogen or lower alkyl group;
• and their pharmaceutically acceptable salts.