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US 4,727,072 AGranted
3-alkoxy-2-aminopropylamines compositions and use as cardiovascular agents
AssigneeMcNeilab, Inc.
InventorsPhilip P. Grous, Richard J. Mohrbacher
Life of this patent
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Abstract
Propylamines of the formula (I): ##STR1## and isomers thereof, particularly those enantiomers and racemates relative to the chiral carbon indicated by an asterisk (*). The propylamines can be used for the treatment of hypertension or angina in humans. A is pyrrolidine, piperidine or morpholine and B is an aromatic heterocycle, aromatic carbocycle or saturated carbocycle.
Claims19
A propylamine of the following formula (I):
- ##STR6## wherein R.sup.1 is a lower alkyl group and R.sup.2 and R.sup.3 are joined to form a cycloalkyl group of about 3 to 7 carbons or R.sup.1, R.sup.2 and R.sup.3 are joined to form a polycyclicalkyl group of about 7 to 12 carbons;
- m is 0 or 1;
- A represents the atoms necessary to form a pyrrolidine, piperidine or morpholine ring;
- Y is independently selected from the group consisting of halo, alkyl, alkoxy, trifluoromethyl, hydroxy, or, when n is 2 on adjacent carbons, methylenedioxy;
- n is 0, 1, 2 or 3;
- and
- B represents the atoms necessary to form an aromatic heterocyclic ring, a saturated carbocyclic ring or an aromatic carbocyclic ring wherein said aromatic carbocyclic ring is either unsubstituted or is independently substituted by 1 or 2 of halo, alkyl, alkoxy, trifluoromethyl, hydroxy, monoalkylamino, dialkylamino or methylenedioxy;
- and the pharmaceutically acceptable acid addition salts thereof.
5 more elements
Dependencies are inferred from the claim text.