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US 4,727,068 AGranted
Radiosensitization by cobalt and Fe(III) complexes
AssigneeJohnson Matthey PLC
InventorsMichael Abrams, Beverly Teicher
Life of this patent
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Abstract
Hypoxic cells are rendered more sensitive to destruction by X-rays or other high energy radiation by treatment with cobalt or iron coordination compounds.
Claims4
A method for rendering hypoxic cells more sensitive to irradiation which comprises subjecting the cells to treatment with a Co(III) or Fe(III) coordination compound selected from the group consisting of:
- (1) compounds having the formula:
- [CoN.sub.n X.sub.6-n ].sup.y (1)
- where
- n has a value of 3 or 4;
- N is an uncharged nitrogen donor atom that is contained in a ligand;
- X represents an anionic ligand;
- and
- y represents the charge on the complex;
- (2) compounds having the formula:
- [CoA.sub.2 X.sup.l D].sup.y.sbsb.1 (2)
- where
- A represents a bidentate or tetradentate negative ligand containing N or O donor atoms;
- X.sup.1 and D represent the same or different monodentate ligands;
- and
- y.sup.1 represents a positive or negative charge on the complex;
- (3) compounds having the formula:
- [CoZ.sub.3 ] (3)
- where Z represents a chelating mononegative negative ligand;
- and
- (4) compounds of the formula:
- [Fe TT.sup.1 ].sup.+ (4)
- where T and T.sup.1, which may be the same or different, represent mono-negative tridentate ligands.
19 more elements
Dependencies are inferred from the claim text.