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US 4,727,066 AGranted
Esters of 1,4-dihydropyridines and medicaments containing the same
AssigneeCermol S.A.
InventorsCarlos E. Sunkel, Miguel Fau de Casa-Juana, Peter R. Statkow, Danielle Straumann
Life of this patent
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Abstract
The preparation of esters of 1,4-dihydropyridine, useful in the prevention and treatment of cardiovascular disorders such as atheroma, of the formula ##STR1## wherein X is a phenyl moiety and Y is piperazine, piperidine or an amide of a benzenecarboxylic acid, is described.
Claims5
A compound selected from the group consisting of esters of 1,4-dihydropyridine having the following formula ##STR68## in which:
- R is hydrogen or, a saturated or an unsaturated hydrocarbon radical;
- R.sub.2 and R.sub.3, which can be identical or different, are hydrogen or a straight chain alkyl group;
- R.sub.4 is hydrogen or a straight alkyl chain;
- n is a number equaling 0, 1, 2 or 3;
- X is a phenyl radical which can have one to three substituents independently selected from the group consisting of nitro, cyano, azido, alkoxy, alkyl, hydroxy, alkanoyloxy, carbalkoxy, amino, alkanoyl, alkylamino, S(O).sub.m -alkyl where m equals 0, 1 or 2, phenyl, trifluoromethyl or halo;
- R.sub.1 is a straight or branched, saturated, unsaturated or cyclic hydrocarbon radical which can be interrupted by one or two atoms of oxygen or sulfur and which can be substituted by one or two hydroxyl groups;
- R.sub.1 can also designate the ##STR69## group;
- where Y is a N-substituted amide of nicotinic, salicylic or hydroxybenzoic acid or a monoalkylated, monoacylated or sulfonated N-substituted piperazine of the formula ##STR70## where R.sub.5 is an acetyl, 2-furoyl, 2-thiophenecarbonyl, cinnamoyl or an arylsulfonyl radical;
- or Y is a N-(4-benzoyl-piperidinyl) group;
- and salts thereof.
7 more elements
Dependencies are inferred from the claim text.