Bis-(2-ammonium-2-hydroxymethyl-1,3-propaned iol(2R-cis)-(3-methyloxiranyl)-phosphonate, a method of preparing same, and pharmaceutical compositions containing same
AssigneeZambon S.p.A.
InventorsDario Chiarino, Davide Della Bella, Vittorio Ferrari
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Abstract
Bis-(2-ammonium-2-hydroxymethyl-1,3-propanediol)(2R-cis)-(3-methyloxiranyl) -phosphonate showing high bioavailability and tolerability is disclosed, as well as a method for preparing same from (2R-cis)-(3-methyloxiranyl)-phosphoric acid, or a salt thereof, and 2-amino-2-hydroxymethyl-1,3-propanediol, or a salt thereof. Pharmaceutical compositions containing the novel bis-phosphonate; useful for clinical forms of urinary and respiratory infections, are also disclosed.
Claims4
A pharmaceutical composition for oral administration containing from 675 to 5400 mg of a substantially pure bis-(2-ammonium-2-hydroxymethyl-1,3-propanediol)(2R-cis)-(3-methyloxiranyl )-phosphonate in admixture with an inert carrier, said composition being effective against infections due to gram-positive and gram-negative bacteria.
A solid pharmaceutical composition for oral administration containing from 675 to 5400 mg of a substantially pure bis-(2-ammonium-2-hydroxymethyl-1,3-propanediol)(2-R-cis)-(3-methyloxirany l)-phosphonate in admixture with an inert carrier, said composition being effective against infections due to gram-positive and gram-negative bacteria.
An improved method for treating infections in man;
- due to gram-positive and gram-negative pathogenic bacteria, comprising subjecting said bacteria to a composition, administered orally, containing an effective growth-inhibiting amount of a salt which is a substantially pure bis(2-ammonium-2-hydroxymethyl-1.3-propanediol)(2R-cis)-(3-methyloxiranyl) phosphonate.
Dependencies are inferred from the claim text.