Depolymerized and supersulfated heparin, process for its preparation and pharmaceutical compositions
AssigneeSclavo S.p.A.
InventorsAnnamaria Naggi, Giangiacomo Torri
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Abstract
Novel depolymerized and supersulfated heparin having a molecular weight comprised between 2000 and 9000 and a sulfation degree of at least 2.5, in which all of the primary hydroxy groups are sulfated; a process for its preparation by reacting a heparin of natural origin, or a fraction thereof with a sulfuric acid/chlorosulfonic acid mixture; and pharmaceutical compositions containing it as active ingredient, having potential antithrombotic, hypolipemic and fibrinolytic activity and useful in the prevention of thrombosis and for the treatment of atherosclerosis.
Claims17
A depolymerized and supersulfated heparin having a molecular weight between 2000 and 9000 and a sulfation degree of at least 2.5, represented by the following formula ##STR11## wherein A represents H and SO.sub.3.sup.-, B represents SO.sub.3.sup.- and COCH.sub.3 and m is an integer from 4 to 15;
- or a pharmaceutically acceptable salt thereof.
A depolymerized and supersulfated having a molecular weight between 2000 and 9000 and a sulfation degree of at least 2.5, characterized by the dominating structure ##STR12##
Dependencies are inferred from the claim text.