Back to results
US 4,727,061 AGranted
Pharmaceutical preparations having diuretic activity
AssigneeRohm Co., Ltd.
InventorsHerbert J. Kramer, Klaus Lehmann, Colin Liddiard
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
AssigneeRohm Co., Ltd.
InventorsHerbert J. Kramer, Klaus Lehmann, Colin Liddiard
Estimating the term…
Pharmaceutical preparations having diuretic activity and comprising a peptide of the formula ##STR1## wherein (a) R.sub.1 and R.sub.2 are hydrogen and R.sub.3 is --OH, or ##STR2## or Y, or wherein (b) R.sub.1 is hydrogen, R.sub.2 is CH.sub.2 OH or ##STR3## and R.sub.3 is --OH or Y, or wherein (c) R.sub.1 is --CH.sub.2 OH and R.sub.2 is hydrogen or ##STR4## and R.sub.3 is --OH or Y, or wherein (d) R.sub.1 is ##STR5## R.sub.2 is hydrogen or --CH.sub.2 OH and R.sub.3 is --OH, --NHCH.sub.2 COOH, or Y, and wherein X is hydrogen, methyl, prolyl, or an N-protective group, and Y is --NH.sub.2, --OR.sub.4, wherein R.sub.4 is linear or branched alkyl or cyclolalkyl having from 1 to 8 carbon atoms, benzyl, phenyl, or ##STR6##
The method of inducing diureses in a patient in need of such treatment, which method comprises orally of parenterally administering to said patient a diuretically effective amount of peptide of the formula ##STR16## wherein (a) R.sub.1 and R.sub.2 are hydrogen and R.sub.3 is --OH, or ##STR17## or Y, or wherein (b) R.sub.1 is hydrogen, R.sub.2 is --CH.sub.2 OH or ##STR18## and and R.sub.3 is --OH or Y, or wherein (c) R.sub.1 is --CH.sub.2 OH, R.sub.2 is hydrogen or ##STR19## and R.sub.3 is --OH or Y, or wherein (d) R.sub.1 is ##STR20## R.sub.2 is hydrogen or --CH.sub.2 OH, and R.sub.3 is --OH, --NHCH.sub.2 COOH, or Y,
A pharmaceutical preparation having diuretic activity, comprising a pharmaceutical carrier selected from the group consisting of orally-administrable and parenterally-administrable pharmaceutical carriers a calcium antaganist, and a diuretically effective amount of a peptide of the formula ##STR22## wherein (a) R.sub.1 and R.sub.2 are hydrogen and R.sub.3 is --OH, or ##STR23## or Y, or wherein (b) R.sub.1 is hydrogen, R.sub.2 is --CH.sub.2 OH or ##STR24## and R.sub.3 is --OH or Y, or wherein (c) R.sub.1 is --CH.sub.2 OH, R.sub.2 is hydrogen or ##STR25## and R.sub.3 is --OH or Y, or wherein (d) R.sub.1 is ##STR26## R.sub.2 is hydrogen or --CH.sub.2 OH, and R.sub.3 is --OH, --NHCH.sub.2 COOH, or Y,
Dependencies are inferred from the claim text.