Human monoclonal antibodies to cytokeratin
AssigneeSloan-Kettering Institute for Cancer Research
InventorsRichard J. Cote, Timothy M. Thomson, Alan N. Houghton, Herbert F. Oettgen, Lloyd J. Old
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Abstract
Human monoclonal antibodies (HmAbs) capable of reacting with cytokeratin are disclosed. It has been found that HmAbs De8, M54, M307, Hull, C29, Hu22 and Pa24 may be used to detect these cytoskeletal proteins in various cells. By means of these HmAbs the embryological origin of cells may be determined. This information may be used to determine the possible tissue source of metastasized tumors and greatly affects the management of these cancers.
Claims5
A hybridoma cell line producing a monoclonal antibody which specifically bind to cytokeratin in human cells, said hydridoma selected from the group consisting of C29 (HB8578), Hull (HB8566) and Hu22 (HB8567).
Method of detecting cytokeratin in human cells comprising contacting said cells with a human monoclonal antibody selected from the group consisting of C29 (HB8578), Hull (HB8566) and HU 22 (HB8567) which specifically binds to said cytokeratin and detecting formation of complexes between said monoclonal antibody and said cytokeratin.
Dependencies are inferred from the claim text.