Immunoregulation of transplantable tissue
OwnerRonald D. Eichner, Arno Mullbacherinventors
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Abstract
Donor tissue is treated prior to implantation in a recipient with a compound from the class known as epipolythiodioxopiperazines in order to prevent graft rejection.
Claims4
A method of treating transplantable biological material to produce anti-phagocytic and immunomodulating properties comprising contacting said material with an effective amount of a compound of the general formula (1):
- ##STR4## alone or in association with one or more pharmaceutically acceptable carriers or diluents
- wherein R.sup.o and R.sup.1 are radicals selected from the group consisting of hydrogen, hydroxy, alkyl, alkoxy and acyloxy;
- R.sup.2 and R.sup.3 are radicals separately selected from the group consisting of hydrogen and alkyl;
- or together, represent a radical of the general formula (2):
- ##STR5## wherein R.sup.5, R.sup.6, R.sup.7, R.sup.8 and R.sup.9 are radicals separately selected from the group consisting of hydrogen, alkyl, hydroxy, alkoxy, sulfate, and halogen;
- or R.sup.2 and R.sup.3 together, represent a radical of the general formula (3):
- ##STR6##
A method of treating biological material for transplantation to a recipient, said method comprising incubating said material prior to transplantation, alone or in association with one or more pharmaceutically acceptable carrier or diluents, with an effective amount of a compound of the general formula (1).
Dependencies are inferred from the claim text.