Preparation of coated granular ibuprofen microsphere
AssigneeShowa Shinyaku Co., Ltd.
InventorsYoshiaki Kawashima, Hirofumi Takeuchi, Toshiyuki Niwa, Tetsurou Handa
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Abstract
This invention provides a simple method for preparing granular ibuprofen microsphere whose surface is coated with acrylic acid resin. By this method granulation of ibuprofen and coating of its surface can be simultaneously accomplished. Namely, the method of preparation includes the steps of: (a) dissolving ibuprofen with acrylic acid resin into lower aliphatic alcohol, acetone, methylene chloride or N,N-dimethylformamide; and (b) depositing coated granular ibuprofen microsphere by mixing the solution of step (a) with water and by stirring the mixed solution.
Claims19
A method for preparing coated granular ibuprofen microsphere, the method comprising of the following steps:
- (a) dissolving ibuprofen with acrylic acid resin in ethanol;
- and
- (b) depositing coated granular ibuprofen microsphere by mixing the solution of step (a) with water and by stirring the mixed solution.
Dependencies are inferred from the claim text.