Medical material and process for its production
AssigneeMitsubishi Monsanto Chemical Company
InventorsTsutomu Sawada, Kyoji Yoshida, Shozo Takano, Masanori Fujikawa
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Abstract
A medical material comprising a shaped article made of a soft vinyl chloride resin composition, a layer formed on the shaped article and composed essentially of crosslinked gelatin having good bio-compatibility with a living body, and an intermediate bonding layer firmly bonding the crosslinked gelatin layer to the shaped article.
Claims8
A process for producing a medical material, which comprises (1) uniformly wetting the surface of a shaped article made of a soft vinyl chloride resin composition, with a gelatin solution to form a non-crosslinked gelatin coating layer in a wet state, (2) contacting a solution of a crosslinking agent to the coating layer to crosslink the non-crosslinked gelatin coating layer, (3) removing any excessive solution of the crosslinking agent from the surface of the shaped article, and (4) contacting the crosslinked gelatin layer of the shaped article to pyrogen-free water at a temperature of from 50.degree. to 80.degree. C. for at least two hours for cleaning.
A process for producing a blood transportation tube, which comprises:
- a first step of filling a tube made of a soft vinyl chloride resin composition, with a solution of a composition for forming a bonding layer, to uniformly wet the inner surface of the tube with the solution, then removing most of the solution from the tube, and drying the layer of the solution uniformly remaining on the inner surface of the tube to form a bonding layer;
- a second step of filling the tube with a gelatin solution to uniformly wet the surface of the bonding layer with the gelatin solution, then removing most of the gelatin solution from the tube to form a non-crosslinked gelatin layer in a wet state on the surface of the bonding layer, thereafter filling the tube with a solution of a crosslinking agent for a non-crosslinked gelatin layer, to crosslink the non-crosslinked gelatin layer, and removing the solution of the crosslinking agent from the tube;
- a third step of filling the tube with a plasticizing solution for the crosslinked gelatin layer, to have the plasticizing solution absorbed in the crosslinked gelatin layer in a wet state;
- and
- a fourth step of removing the plasticizing solution for the crosslinked gelatin layer from the tube and drying the inside of the tube.
Dependencies are inferred from the claim text.