Irradiation of blood products
AssigneeBaxter Travenol Laboratories, Inc.
InventorsJeffrey E. Miripol, Arnold Bilstad, John Foley, Dean Glash
Life of this patent
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Abstract
A thin film of white blood cells is irradiated with ultraviolet radiation predominately of a wavelength of 280 to 320 nanometers, and preferably at an intensity of 4 to 15 milliwatts per square cm. At such a radiation intensity it is not necessary to agitate the thin film of white blood cells to accomplish the purposes of this invention. The white blood cells so processed substantially lose their capability to set off an immune reaction in an alloimmunized patient. The white blood cells may preferably be placed into such film in a flat, flexible bag made of poly(ethylene-vinyl acetate) plastic, with the flat, flexible bag being stretched in a direction normal to the path of ultraviolet radiation.
Claims18
The method of treating white blood cells comprising irradiating a thin film of a blood product containing white blood cells with ultraviolet radiation predominately of a wavelength of 280 to 320 nanometers at an intensity of 4 to 15 milliwatts per square cm., to provide a total energy exposure of 800 to 2800 millijoules per square cm. of ultraviolet radiation for a sufficient time, whereby said white blood cells substantially lose their capability to set off an immune reaction in an alloimmunized patient.
The method of treating white blood cells comprising irradiating a thin film of blood product containing white blood cells with ultraviolet radiation predominately of a wavelength of 280 to 320 nanometers, which comprises:
- presenting said blood product to the radiation while said blood product occupies a flat, flexible bag made of poly(ethylene-vinyl acetate) plastic, said plastic containing from 10 to 30 percent of vinyl acetate units, and said bag having a wall thickness of 0.005 to 0.025 inch, whereby said white blood cells substantially lose their capability to set off an immune reaction in an aloimmunized patient.
The method of treating white blood cells comprising irradiating a thin film of blood product containing white blood cells with ultraviolet radiation predominately of a wavelength between 280 to 320 nanometers at an intensity of 7 to 11 milliwatts per square cm., without agitation of the film, to provide a total energy exposure of 800 to 2800 millijoules per square cm. of ultraviolet radiation, in which said blood product is irradiated while occupying a flat, flexible bag which is stretched during said irradiation to define said thin film of white blood cells within said bag, said bag being made of poly(ethylene-vinyl acetate) plastic.
Dependencies are inferred from the claim text.