Method for producing oncolysis
AssigneeTherapeutical Systems Corp.
InventorClarence D. Cone, Jr.
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Abstract
A method of producing oncolysis and regression of malignant tumors and other malignant conditions without adverse effects on normal body cells is described. A calorically and compositionally defined nutritional regimen providing a minimum of amino acids and fatty acids and a maximum of carbohydrates is administered concurrently with a drug regimen of an agent or agents that uncouple oxidative phosphorylation, most preferably 2,4-dinitrophenol.
Claims30
A method for effecting oncolysis in a mammal with a malignant condition characterized by an in vivo metabolism in the cells wherein said cells are substantially unable to utilize glucose for the production of adenosine triphosphate (ATP), which method comprises elevating said mammal's basal metabolic rate as far as therapeutically tolerable by administering a combination of
- (a) a predetermined periodic dosage of physiologically tolerable agent capable of uncoupling oxidiative phosphorylation in said mammal, and
- (b) a daily nutritional regimen selected with reference to the basal and active metabolic rates of said mammal so as to provide only a minimum daily caloric requirement for said mammal, which is allocated among,
- (i) an amount of amino acids just sufficient to maintain minimal bodily nitrogen balance,
- (ii) a minimum amount of essential fatty acids, and
- (iii) the balance in the form of glucose or physiological precursors thereof.
A method of selectively decreasing the rate of ATP production in malignant cells of a mammal without substantially altering the rate of ATP production in the normal cells of said mammal, wherein the malignant cells undergo in vivo metabolism according to the metabolic pathway depicted in FIG. 2 hereof, which method comprises elevating said mammal's basal metabolic rate as far as therapeutically tolerable by administering a combination of
- (a) a predetermined periodic dosage of physiologically tolerable agent capable of uncoupling oxidative phosphorylation in said mammal, and
- (b) a daily nutritional regimen selected with reference to the basal and active metabolic rates of said mammal so as to provide only a minimum daily caloric requirement for said mammal, which is allocated among,
- (i) an amont of amino acids just sufficient to maintain minimal bodily nitrogen balance,
- (ii) a minimum amount of essential fatty acids, and
- (iii) the balance in the form of glucose or physiological precorsors thereof.
Dependencies are inferred from the claim text.