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US 4,724,207 AGranted
Modified siliceous chromatographic supports
AssigneeCuno Incorporated
InventorsKenneth C. Hou, Tung-Ping D. Liao
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Abstract
A modified silica material which comprises silica covalently bonded to a synthetic polymer, the synthetic polymer being made from (a) a polymerizable compound capable of being covalently coupled directly to said silica, and (b) one or more polymerizable compounds containing (i) an ionizable chemical group, (ii) a chemical group capable of transformation to an ionizable chemical group, (iii) a chemical group capable of causing the covalent coupling of the compound (b) to an affinity ligand or a biologically active molecule or (iv) a hydrophobic compound.
Claims36
A modified silica material which comprises:
- (1) silica covalently bonded to a synthetic polymer;
- (2) said synthetic polymer comprising a copolymer made from a free-radical polymerization of
- (a) a polymerizable compound containing an epoxy group capable of direct covalent coupling to a hydroxy group of said silica and a vinyl group, capable of free-radical polymerization;
- and
- (b) a polymerizable compound having the formula ##STR10## wherein R is an alpha, beta-ethylenically unsaturated polymerizable radical, R' and R" are the same or different C.sub.1 -C.sub.6 alkyl or alkanoyl groups, and R'" is a direct bond or a C.sub.2 -C.sub.3 alkyl group, wherein R' and R", taken together with the N atom may form a heterocyclic ring.
2 more elements
Dependencies are inferred from the claim text.