Derivatives of alpha-alkyl polyolefinic carboxylic acid useful in the treatment of psoriasis
AssigneeUSV Pharmaceutical Corporation
InventorsBernard Loev, Howard Jones, Wan-kit Chan
Life of this patent
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Abstract
This invention relates to novel compounds having pharmaceutical activity and having the general structure ##STR1## wherein the Z, R.sub.1, R.sub.2, R.sub.3, R.sub.4, n and m are defined within.
Claims11
Compounds of the structure ##STR8## wherein n is 0 to 3,
- m is 0 to 1, and
- R.sub.1 and R.sub.4 are each independently hydrogen or an alkyl group of from 1 to 5 carbon atoms;
- R.sub.2 is an alkyl group of from 1 to 5 carbon atoms;
- R.sub.3 is ##STR9## retinoyloxy, or ##STR10## R.sub.5 is independently H, C.sub.1 -C.sub.20 alkyl, aryl, aralkyl, and Z is a cycloalkyl, cycloalkenyl or cyclodialkenyl group substituted with from 0 to 5 C.sub.1 -C.sub.5 alkyl groups, a keto group or a hydroxyl group, or a phenyl group substituted with from 0 to 4 hydroxy, C.sub.1 -C.sub.5 alkoxy, C.sub.1 -C.sub.5 alkyl or trifluoromethyl groups or halogen atoms or combinations thereof;
- and the pharmaceutically-acceptable salts thereof.
2,5,9-Trimethyl-11-(2,6,6-trimethyl-1-cyclohexen-1-yl)2,4,6,8,10 -undecapentaenyl acetate.
2,5,9-Trimethyl-11-(2, 6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8,10-undecapentaenyl palmitate.
2,5,9-Trimethyl-11-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8,10-u ndecapentaenyl retinoate.
2,5,9-Trimethyl-11-(2 ,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8,10-undecapentaenyl 2,5,9-trimethyl-11-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8,10-undecape ntaenoate.
2,7-Dimethyl-9-(4-methoxy-2,3,6-trimethylphenyl)-2,4,6,8-nonatetraenyl palmitate.
Dependencies are inferred from the claim text.