Method for immunizing animals with synthetically modified vaccinia virus
AssigneeHealth Research, Inc.
InventorsEnzo Paoletti, Dennis Panicali
Life of this patent
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Abstract
What are disclosed are methods for modifying the genome of vaccinia virus to produce vaccinia mutants, particularly by the introduction into the vaccinia genome of exogenous DNA; modified vaccinia prepared by such methods; certain DNA sequences and unmodified and genetically modified microorganisms involved as intermediates in such methods; and methods for infecting cells and host animals with such vaccinia mutants to provoke the amplification of exogenous DNA and proteins encoded by the exogenous DNA, including antigenic proteins, by said cells and host animals.
Claims7
The method of amplifying a protein which comprises inoculating a host animal, susceptible to vaccinia virus, with a recombinant vaccinia virus synthetically modified by the presence, in a non-essential region of the vaccinia genome, of DNA not naturally occurring in vaccinia virus and coding for said protein.
The method of immunizing a host animal, susceptible to vaccinia virus, by inducing an immunological response in said animal, which method comprises inoculating said animal with a vaccinia virus synthetically modified by recombination to have, within a non-essential region of the vaccinia genome, DNA not naturally occurring in the vaccinia virus, said DNA coding for an antigen inducing said immunological response.
Dependencies are inferred from the claim text.