Pyridazine derivatives active on the central nervous system, and medicaments in which they are present
AssigneeSanofi
InventorsJean-Pierre Chambon, Kathleen Biziere, Camille-Georges Wermuth
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Abstract
The invention relates to the pyridazine derivatives of the formula: ##STR1## in which R.sub.1 is H, a substituted or unsubstituted phenyl group, a naphthyl group, a cyclohexyl group, a thien-2-yl group, a thien-3-yl group or an indol-3-yl group, R.sub.2 is H or an alkyl or phenyl group, R.sub.3 is H, an alkyl, or phenyl group in formula Ib and a cyano group in formula Ia, and Alk is (CH.sub.2).sub.n where n is 2, 3 or 4, or --CH.sub.2 --C.ident.C--, and X.sup.- is halide, a process for the preparation of the said products and their application as medicaments.
Claims21
A pyridazine compound having a formula:
- ##STR47## in which:
- R.sub.1 denotes hydrogen, a lower alkyl group, a phenyl group, a phenyl group monosubstituted by a halogen, a nitro group, a lower alkyl group, a lower alkoxy group, a hydroxyl group or a trifluoromethyl group;
- a phenyl group disubstituted by halogen;
- a naphthyl group, a cyclohexyl group, a thien-2-yl group, a thien-3-yl group or an indol-3-yl group;
- R.sub.2 represents hydrogen, a lower alkyl group or a phenyl group;
- R.sub.3 represents a cyano group;
- Alk represents a group (CH.sub.2).sub.n, in which n is an integer equal to 2, 3 or 4, or a 1,2-propynyl group --CH.sub.2 C.ident.C--;
- and
- R.sub.4 represents:
- --COOH
- --COO-alkyl
- --CONH.sub.2
- --C.ident.N
- wherein alkyl is lower alkyl;
- and the addition salts of said derivatives with acids.
A pyridazine compound having a formula ##STR48## in which:
- R.sub.1 denotes hydrogen, a lower alkyl group, a phenyl group, a phenyl group monosubstituted by a halogen, a nitro group, a lower alkyl group, a lower alkoxy group, a hydroxyl group or a trifluoromethyl group;
- a phenyl group disubstituted by halogen;
- a naphthyl group, a cyclohexyl group, a thien-2-yl group, a thien-3-yl group or an indol-3-yl group;
- R.sub.2 represents hydrogen, a lower alkyl group or a phenyl group;
- R.sub.3 represents hydrogen, a lower alkyl group, or a phenyl group;
- Alk represents a group (CH.sub.2).sub.n, in which n is an integer equal to 2, 3 or 4, or a 1,2-propynyl group --CH.sub.2 C.ident.C--;
- and
- R.sub.4 represents:
- --COOH
- --COO-alkyl
- --CONH.sub.2
- --C.ident.N
- wherein alkyl is lower alkyl;
- and the addition salts of said derivatives with acids.
Dependencies are inferred from the claim text.