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AssigneeCiba-Geigy Corporation
InventorsHendrik S. Jansz, Cornelis J. M. Lips, Paul H. Steenbergh, Hans Rink, Peter Sieber
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Described are peptides that have, as partial sequence of a larger peptide, or exclusively, the amino acid sequence of the formula I ##STR1## in which the cysteine residues can form intra- or inter-molecular disulphide bridges, and derivatives thereof having an amidated terminal carboxy group and/or an acylated terminal amino group, and their salts, DNA sequences that code for the mentioned peptides, micro-organisms that contain these DNA sequences, processes for the manufacture thereof, pharmaceutical preparations that contain the mentioned peptides in the form of their amides, and the use of these peptide-amides for the treatment of coronary circulation disorders and bone metabolism disorders.
A peptide fragment of human calcifonin gene related peptide of at least 37 amino acids up to 90 amino acids containing at least the 37 amino acid sequence of the formula ##STR24## the Cys resides within said 37 amino acid sequence being free or forming an intra- or inter-molecular disulfide bridge, said peptide being a fragment of human calcitonin gene related peptide;
The peptide of the formula ##STR26## or a pharmaceutically acceptable salt thereof.
The peptide of the formula ##STR27## or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.