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US 4,720,353 AGranted
Stable pharmaceutical w/o emulsion composition
AssigneeRichardson-Vicks Inc.
InventorStephen R. Bell
Life of this patent
Estimating the term…
Abstract
A stable water-in-oil emulsion composition for topical therapeutic administration comprising: a. a dispersed aqueous phase comprising water optionally containing a pharmaceutically acceptable electrolyte dissolved therein; b. a pharmaceutically acceptable continuous oil phase comprising mineral oil and a volatile silicone fluid; c. an organopolysiloxane emulsifier of Formula (I) hereinafter described; d. PPG-20 Methyl Glucose Ether Distearate; and e. an active drug component for topical application.
Claims8
A stable water-in-oil emulsion composition comprising:
- a. a dispersed water phase comprising water optionally containing a pharmaceutically acceptable electrolyte dissolved therein;
- b. a pharmaceutically acceptable continuous oil phase comprising mineral oil and a volatile silicone fluid selected from the group consisting of octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane and mixtures thereof dissolved therein;
- c. an organopolysiloxane of the average formula:
- ##STR4## wherein R is hydrogen or C.sub.1-4 alkyl;
- n is a number between 10 and 200;
- m is a number between 1 and 25;
- o is a number between 1 and 100, provided that all o>m;
- p is a number between 7 and 17;
- and the molar weight of (C.sub.2 H.sub.4 O--).sub.x (C.sub.3 H.sub.6 O--).sub.y R is between 250 and 2000, in which x and y are such that the weight ratio of oxyethylene (C.sub.2 H.sub.4 O--) groups to oxypropylene (C.sub.3 H.sub.6 O--) groups is between 100:0 to 20:80.
- d. PPG-20 Methyl Glucose Ether Distearate;
- and
- e. an effective therapeutic amount of a topically active drug.
9 more elements
Dependencies are inferred from the claim text.