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US 4,716,175 AGranted
Saturated fatty acid amides as inhibitors of acyl-CoA:cholesterol acyltransferase
AssigneeWarner-Lambert Company
InventorsMilton L. Hoefle, Ann Holmes, Bruce D. Roth
Life of this patent
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Abstract
Certain substituted amides of saturated fatty acids are potent inhibitors of the enzyme acyl-CoA:cholesterol acyltransferase and are thus useful agents for inhibiting the intestinal absorption of cholesterol.
Claims7
A compound having the formula:
- ##STR3## wherein A is an unbranched hydrocarbon group containing from one to twenty carbon atoms and which may contain from one to three carbon-carbon double bonds;
- R.sub.1 is hydrogen, alkyl of from one to four carbon atoms or phenylmethyl;
- R.sub.2 is alkyl of from one to four carbon atoms or phenylmethyl;
- or
- R.sub.1 and R.sub.2 when taken together with the carbon atom to which they are attached form a saturated carbocyclic ring of from three to seven carbon atoms;
- B is selected from ##STR4## where n is zero or one, R.sub.3, R.sub.4, and R.sub.5 are independently selected from
- hydrogen, fluorine, chlorine, bromine, trifluromethyl, alkyl of from one to four carbon atoms, and alkoxy of from one to four carbon atoms;
4 more elements
Dependencies are inferred from the claim text.