Purified AIDS-associated virus ARV-2
AssigneeThe Regents of the University of California
InventorJay A. Levy
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Abstract
A newly discovered family of AIDS-associated viruses, designated ARV, is described. The viruses were isolated from AIDS patients from San Francisco and (a) are type D retroviruses; (b) have Mg.sup.++ -dependent reverse transcriptase activity; (c) induce human multinucleated cells without immortalizing the cells; (d) are replicable in HUT-78 human T cells; and (e) induce viral protein(s) in HUT-78 that binds to Ig from AIDS patients. The infected HUT-78 cells and immunogenic polypeptides derived from the viruses are useful for diagnosing AIDS.
Claims9
Biologically pure AIDS-associated retrovirus, ARV-2, said retrovirus having all the identifying characteristics of the ARV-2 retrovirus that has infected the human T-cell line, ATCC CRL 8597.
Dependencies are inferred from the claim text.