Temperature sensitive strain of bovine viral diarrhoea virus
AssigneeSmithKline-RIT
InventorsJean-Claude Delgoffe, Michele Lobmann, Nathan Zygraich
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Abstract
Disclosed is a temperature - sensitive (ts) mutant of bovine viral diarrhoea (BVD) virus which shows a considerably limited replication ability at the animal body temperature. The mutant is prepared by reacting wild-type BVD with a chemical mutagen such as nitrous acid. The mutant virous is advantageously used in vaccine compositions because it is capable of inducing immunity in bovines without causing serious side effects.
Claims1
An isolated and purified temperature sensitive strain of bovine viral diarrhoea virus having the temperature sensitive growth characteristics of the C.N.C.M. I-199 virus strain.
Dependencies are inferred from the claim text.