US 4,713,455 A · Cyclic derivatives of alkyl dihydroxyalkylxanthenes

Abstract

Compounds of the formula ##STR1## wherein one of the radicals R.sup.1, R.sup.2 or R.sup.3 denotes a straight-chain alkyl group having 4 to 8 C atoms and two vicinal hydroxyl groups in the .omega.,.omega.-1 or .omega.-1,.omega.-2 positions and the two other radicals represent straight-chain or branched alkyl groups having up to 12 C atoms in the position of R.sup.1 and R.sup.3 and up to 4 C atoms in the position of R.sup.2, the total of C atoms in these two alkyl substituents being a maximum of 14, are prepared by oxidation of the corresponding alkenylxanthines and by alkylation with compounds which introduce the dihydroxyalkyl radical or a precursor thereof. The dihydroxyalkyldialkylxanthines are suitable for the treatment of obstructive respiratory tract diseases.

Claims11

Dependent claims

A compound of the formula ##STR105## in which one of the radicals R.sup.1, R.sup.2 and R.sup.3 represents a group of formula IV ##STR106## or formula IX ##STR107## R.sup.4 denoting hydrogen or methyl;

R.sup.6 and R.sup.7, independently of one another, being hydrogen, lower alkyl, phenylalkyl having up to 2 C atoms in the alkyl moiety or phenyl;
n, when R.sup.4 is hydrogen, denoting an integer from 2 to 6 and, when R.sup.4 is methyl, denoting 1 to 5, the rest of the radicals R.sup.1, R.sup.2 and R.sup.3, independently of one another, denoting hydrogen or alkyl having 1 to 12 C atoms in the positions R.sup.1 and R.sup.3 and having 1 to 4 C atoms in the position R.sup.2, the total number of carbon atoms in these two radicals being a maximum of 14.

Dependencies are inferred from the claim text.

Cyclic derivatives of alkyl dihydroxyalkylxanthenes

Life of this patent

Cyclic derivatives of alkyl dihydroxyalkylxanthenes

Life of this patent

Abstract

Claims11