Phenolic thioethers as inhibitors of 5-lipoxygenase

A compound of the formula:

• ##STR53## or a pharmaceutically acceptable salt thereof wherein R.sub.1 and R.sub.2 are the same or different and independently represent tert-alkyl or phenyl;
• A represents methylene or methylene substituted by alkyl, dialkyl or hydroxy, provided that when A includes hydroxymethylene, the hydroxymethylene group is not adjacent to a heteroatom;
• B represents sulfur, sulfoxide, sulfone, oxygen, --NH-- or nitrogen substituted by alkyl, phenyl, benzyl, phenyl substituted by one or two substituents which may be the same or different and are independently selected from the group consisting of halogen, C.sub.1 -C.sub.6 alkyl, hydroxy, C.sub.1 -C.sub.6 -alkoxy, acetoxy, carboxylic acid and C.sub.1 -C.sub.6 alkyl esters thereof, nitro or phenyl or benzyl substituted by one or two substituents which may be the same or different and are independently selected from the group consisting of halogen, C.sub.1 -C.sub.6 alkyl, hydroxy, C.sub.1 -C.sub.6 alkoxy, acetoxy, carboxylic acid and C.sub.1 -C.sub.6 alkyl esters thereof, nitro or phenyl;
• C represents methylene or methylene substituted by alkyl;
• R.sub.3 represents CO.sub.2 H, CO.sub.2 -alkyl, or a tetrazole group;
• m is 0 or 1, n is 2, 3, or 4 and p is 1, 2, or 3.