.alpha., .omega.-dicarboxylic acids and medicaments which contain these compounds
AssigneeEpis S.A.
InventorsJacob Bar-Tana, Ernst-Christian Witte, Bernd Hagenbruch, Johannes Pill, Karlheinz Stegmeier
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Abstract
The abstract isn’t available for this document.
Claims8
An .alpha.,.omega.-dicarboxylic acid compound of formula I' ##STR10## in which R.sub.1 and R.sub.2, which can be the same or different, signify a C.sub.1 -C.sub.6 lower alkyl group, which is unsubstituted or is substituted by hydroxyl, C.sub.1 -C.sub.6 lower alkoxy, halogen, phenyl or phenyl substituted one or more times by hydroxyl, C.sub.1 -C.sub.6 lower alkoxy, C.sub.1 -C.sub.6 lower alkyl or halogen, a C.sub.2 -C.sub.6 lower alkenyl or C.sub.2 -C.sub.6 alkynyl group;
- a C.sub.3 -C.sub.7 cycloalkyl group, a phenyl group, or a phenyl group substituted by hydroxyl, halogen, C.sub.1 -C.sub.6 lower alkyl or C.sub.1 -C.sub.6 lower alkoxy,
- X and Y, which can be the same or different, signify hydrogen, C.sub.1 -C.sub.6 lower alkyl, C.sub.1 -C.sub.6 lower alkoxy, hydroxyl, cyano, halogen, carboxyl, C.sub.1 -C.sub.6 lower alkoxycarbonyl or carbamoyl, and
- Q represents a --(CH.sub.2).sub.n --cyclohexylidene--(CH.sub.2).sub.n --, a --(CH.sub.2).sub.m --phenylene--(CH.sub.2).sub.m --, a --CH.sub.2 --CH.dbd.CH--phenylene--CH.dbd.CH--CH.sub.2 -- or a --CH.sub.2 --CH.dbd.CH--CH.sub.2 --phenylene--CH.sub.2 --CH.dbd.CH--CH.sub.2 --group, n is 2, 3 or 4 and m is 3 or 4,
- or an in vivo hydrolysable carboxylic acid derivative thereof.
A pharmaceutical composition comprising a lipid sinking or antidiabetic effective amount of a compound selected from the group consisting of 1,4-phenylene-bis-(3,3-dimethyl-6-yl-hexanoic acid) and 1,4-phenylene-bis-(3,3-dimethyl-6-yl-hex-5-enoic acid).
Dependencies are inferred from the claim text.