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US 4,711,884 AGranted
Thiazine and thiazepine containing compounds
AssigneeE. R. Squibb & Sons, Inc.
InventorDonald S. Karanewsky
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Abstract
This invention is directed to compounds of the formula ##STR1## wherein X is a thiazine or thiazepine of the formula ##STR2## These compounds possess angiotensin converting enzyme inhibition activity and are thus useful as hypotensive agents.
Claims6
A compound of the formula:
- ##STR82## and a pharmacuetically acceptable salt salt thereof wherein:
- R.sub.3 is hydroxy, ethyoxy, or -O-alkali metal salt ion;
- R.sub.5 is hydrogen or phenyl;
- R.sub.2 is hydrogen, alkali metal salt ion, or ##STR83## R.sub.10 is hydrogen, straight or branched chain lower alkyl of 1 to 4 carbons, or cyclohexyl;
- and
- R.sub.11 is straignt or branched chain lower alkyl of 1 to 4 carbons.
3 more elements
Dependencies are inferred from the claim text.