Method for percutaneously administering physiologically active agents

A method for percutaneously administering a benzodiazepine to a mammal which comprises applying the physiologically active agent to the skin of the mammal in a mixture comprising at least one of the following components A and at least one of the following components B:

• Component A:
• an alcohol ester of an aliphatic carboxylic acid having a total number of carbon atoms of from 7 to 18 or mixtures thereof;
• Component B:
• a compound represented by the formula:
• ##STR18## wherein R.sub.5 represents a hydrogen atom or a lower alkyl group having 1 to 4 carbon atoms and n represents an integer of 3 to 5 or mixtures thereof, wherein the amount of the component A is form 0.1 to 80% by weight based on the total weight of the components A and B.