Process for the continuous production of L-carnitine
AssigneeLonza Ltd.
InventorsHans Kulla, Pavel Lehky, Armand Squaratti
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Abstract
Process for the continuous production of L-carnitine by the microbiological method. A microorganism of the strain DSM No. 3225 (HK 1331b) type is cultivated in a bioreactor with crotonobetaine and/or .gamma.-butyrobetaine in the presence of a growth substrate. The culture fluid passes outside of the bioreactor in a circulation in which a separation of the cell is carried out. A quantity of cell-free solution, which is as large as the amount fed to the bioreactor as a substrate, is withdrawn from the bioreactor. The L-carnitine is separated from the cell-free solution.
Claims22
A process for the continuous production of L-carnitine comprising cultivating a microorganism of the strain Achromobacter xylosoxydans DSM 3225 (HK 1331b) type in a bioreactor with crotonobetaine and/or .gamma.-butyrobetaine in the presence of a growth substrate, passing the culture fluid outside of the bioreactor in a circulation in which a separation of the cell is carried out, whereby a quantity of cell-free solution, which is as large as the amount fed to the bioreactor as a substrate, is withdrawn from the bioreactor, and separating the L-carnitine from the cell-free solution.
Dependencies are inferred from the claim text.