Antigenically active amino acid sequences
AssigneeCommonwealth Serum Laboratories Commission
InventorHendrik Geysen
Life of this patent
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Abstract
A synthetic peptide which displays the antigenicity of the VP1 protein of foot-and-mouth disease virus, characterised in that at least a portion of said peptide is selected from the group consisting of five-, six- or seven-long antigenically active amino acid sequences of said VP1 protein, and antigenically active modified sequences thereof.
Claims18
A synthetic peptide which displays the antigenicity of the VP1 protein of foot-and-mouth disease virus, Type O.sub.1, wherein said peptide is selected from amino acid sequences of the group consisting of:
- (i) G - D - L - Q - V - L - A;
- (ii) G - D - L - Q - V - L;
- (iii) D - L - Q - V - L - A;
- (iv) D - L - Q - V - L;
- and
- (v) antigenically acitve modified sequences based on any one of the sequences (i) to (iv) above in which one of the amino acids in said sequences (i) to (iv) above is replaced by another amino acid to provide said antigenically active modified sequences.
A synthetic peptide which displays the antigenicity of the VP1 protein of foot-and-mouth disease virus, Type A.sub.10 (A.sub.61), wherein said peptide is selected from amino acid sequences of the group consisting of:
- (i) G - D - L - G - S - I - A;
- (ii) G - D - L - G - S - I;
- (iii) D - L - G - S - I - A;
- (iv) D - L - G - S - I;
- and
- (v) antigenically active modified sequences based on any one of the sequences (i) to (iv) above in which one of the amino acids in said sequences (i) to (iv) above is replaced by another amono acid to provide said antigenically active modified sequences.
A synthetic peptide which displays the antigenicity of the VP1 protein of foot-and-mouth disease virus, Type C.sub.1, wherein said peptide is selected from amino acid sequence of the group consisting of:
- (i) D - L - A - H - L - T - A;
- (ii) D - L - A - H - L - T;
- (iii) L - A - H - L - T - A;
- (iv) L - A - H - L - T;
- and
- (v) antigenically active modified sequences based on any one of the sequences (i) to (iv) above in which one of the amino acids in said sequences (i) to (iv) above is replaced by another amino acid to provide said antigenically active modified sequences.
Dependencies are inferred from the claim text.