9.alpha., 11.beta.-substituted and 11.beta.-substituted estranes
AssigneeSRI International
InventorsDavid F. Crowe, Masato Tanabe, Richard Peters
Life of this patent
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Abstract
9 alpha, 11 beta and 11 beta-substituted estranes are disclosed which exhibit elevated estrogenic and postcoital contraceptive activities. A process for their manufacture and their use in pharmaceuticals is also disclosed.
Claims34
A compound of the formula ##STR7## wherein R.sub.1 is selected from the group consisting of hydrogen, lower alkyl, cycloalkyl and lower acyl;
- and
- R.sub.3 is lower alkoxyl.
A compound of the formula ##STR8## wherein R.sub.1 is selected from the group consisting of hydrogen, lower alkyl, cycloalkyl and lower acyl;
- and
- R.sub.5 is selected from the group consisting of lower alkyl and hydrogen.
A compound of the formula ##STR12## wherein R.sub.1 is selected from the group consisting of hydrogen, lower alkyl, cycloalkyl and lower acyl;
- and
- R.sub.5 is a lower alkyl.
A compound of the formula ##STR13## wherein R.sub.1 is selected from the group consisting of hydrogen, lower alkyl, cycloalkyl and lower acyl;
- R.sub.3 is selected from the group consisting of hydrogen, hydroxyl and lower alkoxy;
- R.sub.4 is a pair of substituents the .alpha. one of which being selected from hydrogen and lower alkynyl, and the .beta. one of which being selected from alkanoic acid esters, lower alkyl and hydroxyl;
- and
- R.sub.5 is selected from the group consisting of lower alkyl and hydrogen, subject to the proviso that if R.sub.4 is an .alpha. hydroxyl and a .beta. alkanoic acid ester or hydrogen, then R.sub.5 must be a lower alkyl.
A compound of the formula ##STR14## wherein R.sub.1 is selected from the group consisting of hydrogen, lower alkyl, cycloalkyl, and lower acyl;
- R.sub.3 is selected from the group consisting of hydrogen, hydroxyl, and lower alkoxy;
- and
- R.sub.5 is a lower alkyl.
Dependencies are inferred from the claim text.