Substrates with sterically-protected, stable, covalently-bonded organo-silane films
AssigneeE. I. Du Pont de Nemours and Company
InventorsJoseph L. Glajch, Joseph J. Kirkland
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Abstract
This invention relates to unique stable support structures comprising substrates coated with sterically-protecting monofunctional silanes. This structure consists of an appropriate reactive solid to which a monofunctional silane is covalently bonded that contains at least two sterically-protecting groups attached to the silicon atom of the silane.
Claims17
A stable support structure comprising a substrate and a monofunctional silane, containing two sterically-protecting groups, R, and an additional functional group, R.sub.1, covalently attached to the substrate, the silane being as follows:
- ##STR4## where R=isopropyl, t-butyl, sec.-butyl, sec. pentyl, isopentyl, or cyclohexyl, R.sub.1 =alkane, substituted alkane, alkene, substituted alkene, aryl, or substituted aryl;
- and A=a surface group of the substrate to which the silane is attached.
A stable support structure for peptide synthesis comprising a silica substrate, and a silane, arranges as follows:
- ##STR5## covalently attached to the silica substrate.
Dependencies are inferred from the claim text.