Back to results
US 4,704,386 AGranted
8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[(phenylsulfinyl-, and phenylsulfonyl)alkanoyl]hydrazides
AssigneeG. D. Searle & Co.
InventorRichard A. Mueller
Life of this patent
Estimating the term…
Abstract
This invention relates to 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[(substituted phenylsulfinyl)alkanoyl]hydrazides and 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[(substituted phenylsulfonyl)alkanoyl]hydrazides that are useful as prostaglandin antagonists and analgesic agents. This invention also relates to 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[(substituted phenylthio)alkanoyl]hydrazides that are useful as intermediates in the preparation of the corresponding sulfinyl and sulfonyl compounds.
Claims14
A compound of the formula:
- ##STR8## wherein X is SO or SO.sub.2 ;
- wherein
- R.sup.1 is:
- (a) hydrogen;
- (b) alkyl or 1 to 4 carbon atoms, inclusive;
- (c) alkoxy of 1 to 4 carbon atoms, inclusive;
- or
- (d) halogen;
- wherein
- R.sup.2 is:
- (a) hydrogen;
- (b) alkyl of 1 to 4 carbon atoms, inclusive;
- (c) alkoxy of 1 to 4 carbon atoms, inclusive;
- or
- (d) halogen;
- and
- wherein n is an integer from 1 to 4 inclusive.
14 more elements
Dependencies are inferred from the claim text.