Compounds useful in treating sickle cell anemia
AssigneeMerck & Co., Inc.
InventorsDonald J. Abraham, Otto W. Woltersdorf, Jr., Edward J. Cragoe, Jr.
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Abstract
The present invention is directed to compounds of the general formula I and pharmaceutically acceptable salts thereof: ##STR1## wherein R=H or lower alkyl; R'=H, lower alkyl, benzyl, CH.sub.2 OH; A=(CH.sub.2).sub.1 to 5, >C(CH.sub.3).sub.2, >C (CH.sub.2).sub.3 ; and X=0 or 1. The present invention is also directed to a method of treating a person for sickle cell anemia comprising administering to the person a therapeutically effective dosage of the above compounds. In addition the invention includes the novel compound: ##STR2## which is inaccessible by synthetic procedures previously described for this general class of compounds.
Claims35
A compound of the general formula and pharmaceutically acceptable salts thereof:
- ##STR11## wherein:
- R=H or lower alkyl;
- R'=H, lower alkyl, benzyl, or CH.sub.2 OH;
- A=(CH.sub.2).sub.1 to 5'>C(CH.sub.3).sub.2' >C(CH.sub.2).sub.3 ;
- and
- X=0 or 1;
- with the proviso that when R is C.sub.2 H.sub.5 and R' is H and X is zero, A cannot be CH.sub.2.
An antisickling pharmaceutical composition comprising a pharmaceutical carrier and an antisickling agent of the general formula and pharmaceutically acceptable salts thereof:
- ##STR12## wherein:
- R=H or lower alkyl;
- R'=H, lower alkyl, benzyl, CH.sub.2 OH;
- A=(CH.sub.2).sub.1 to 5' >C(CH.sub.3).sub.2, or C(CH.sub.2).sub.3 ;
- and
- X=0 or 1.
A method of treating a person for sickle cell anemia comprising administering to the person a therapeutically effective dosage of a compound of the general formula and pharmaceutically acceptable salts thereof:
- ##STR13## wherein:
- R=H or lower alkyl;
- R'=H, lower alkyl, benzyl, or CH.sub.2 OH;
- A=(CH.sub.2).sub.1 to 5, >C(CH.sub.3).sub.2, >C(CH.sub.2).sub.3 ;
- and
- X=0 or 1.
Dependencies are inferred from the claim text.